A crowd of 4,087, which included United manager Louis van Gaal, watched on as a Zach Dearnley goal and a brace from England U17s midfielder Callum Gribbin fired the Red Devils to victory.
The FA Youth Cup
Fourth Round Proper
Tuesday 13 January
The hosts included a number of other Young Lions within their side, as U17 internationals Dean Henderson, Cameron Borthwick-Jackson and U18s attacker Marcus Rashford all featured for the duration.
United will now travel to Tottenham Hotspur or Wolves in the Fifth Round.
Across in the north east, it took extra-time before Sunderland finally overcame Ipswich Town 3-1 at the Stadium of Light.
It was an action-packed affair from the first minute until the 120th, with Jordan Blinco equalising after Victor Gulbrandsson had headed the visitors into the lead, before extra-time goals from Luke Molyneux and Daniel Pybus sealed the win.
Speaking to SAFC.com afterwards, Sunderland boss Elliot Dickman hailed the spirit of his group.
“We often speak about the togetherness and the work ethic displayed by the team and it's what has got us through the game, so I’m really pleased for them because they’ve worked really hard and I think they deserved it on the night.”
The Black Cats will meet rivals Newcastle United in The Fifth Round.