Daniel Sturridge made his long-awaited return from injury on Sunday, but had to settle for a point as Liverpool drew 1-1 against Norwich City.
Sturridge – making his first appearance since April – featured for 63 minutes, before being replaced by fellow England international Adam Lallana.
Premier League results
Tottenham Hotspur 1-0 Crystal Palace
Liverpool 1-1 Norwich City
Southampton 2-3 Man Utd
After an uneventful first half, Danny Ings came off the bench at the break to replace the injured Christian Benteke and scored his first goal in a Liverpool shirt three minutes into the second period.
However, the Canaries – featuring Under-21s international Nathan Redmond – secured a valuable point thanks to Russell Martin’s equaliser 13 minutes later.
England youth internationals Jordon Ibe and Joe Gomez were both named among Brendan Rodgers’ substitutes, but did not make it onto the field.
At White Hart Lane Harry Kane and Kyle Walker were part of the youngest starting 11 of the Premier League season, as a Tottenham side with an average age of 24 years, 118 days overcame Crystal Palace 1-0.
Along with Kane and Walker, England Under-21s' Dele Alli and Eric Dier impressed in partnership in the heart of Tottenham’s engine room.
Son Heung-min’s goal with 22 minutes left proved decisive as Spurs got their season back on track with a second consecutive 1-0 win.
On the south coast Wayne Rooney – who was playing for the first time since he became England’s all-time leading scorer – led Manchester United to victory at St Mary’s as they hung on for a 3-2 victory against Southampton.
The home side, featuring two England Under-21s internationals in the shape of Matt Targett and James Ward-Prowse, had taken the lead through Graziano Pellè before teenager Anthony Martial equalised.
Martial then gave United the lead, before Juan Mata made it 3-1, and although Pellè grabbed another to make it a tense finish, David de Gea’s saves ensured the three points were going back to Manchester with Rooney’s side.
Of the 220 Premier League starters last weekend, 63 can play for England (28.6 per cent). The 2015-16 average to date is 30.1 per cent.