Newcastle United will travel to Crystal Palace in the only confirmed FA Youth Cup fourth round tie, after the draw was made on Friday afternoon.
The Magpies eased past Brighton in round three while Palace edged Mansfield Town on penalties.
Burnley, who saw off Leeds United, will host either Plymouth Argyle or Manchester City and Leicester City will visit either Swindon Town or Nottingham Forest.
And Birmingham City will entertain either Sheffield United or Burton Albion.
The remaining third round ties will be completed by Saturday 16 December.
All fourth round ties must be played by Saturday 20 January 2018.
Fourth round draw
1 Hartlepool United or Liverpool v Arsenal or Sheffield Wednesday
2 Burnley v Plymouth Argyle or Manchester City
3 Crystal Palace v Newcastle United
4 West Ham United or Blackpool v Southampton or Wolverhampton Wanderers
5 Fleetwood Town or Stevenage v Middlesbrough or Bolton Wanderers
6 Chelsea or Scunthorpe United v West Bromwich Albion
7 Everton or Ipswich Town v Oxford United or Dagenham & Redbridge
8 Queens Park Rangers or Charlton Athletic v Reading or Millwall
9 Cheltenham Town or Bury v Aston Villa or Coventry City
10 Colchester United or Crewe Alexandra v Milton Keynes Dons or Cardiff City
11 Birmingham City v Sheffield United or Burton Albion
12 Swindon Town or Nottingham Forest v Leicester City
13 Blackburn Rovers or Stoke City v Watford or Sunderland
14 Swansea City or Chesterfield v Huddersfield Town or Fulham
15 Norwich City or Barnsley v Derby County or Manchester United
16 AFC Bournemouth or Hull City v Tottenham Hotspur or Preston North End
