Yeovil Town, the lowest-ranked side left in the Emirates FA Cup, will entertain Manchester United in the fourth round after the draw was made on Monday evening.
The Glovers defeated Bradford City on Saturday and they will take on the 12-time winners at the end of the month.
Meanwhile, Yeovil’s fellow League Two side Newport County will host eight-time winners Tottenham Hotspur.
Nottingham Forest, who ousted holders Arsenal on Sunday, will travel to 2014 Finalists Hull City.
There are two confirmed all-Premier League ties in the shape of Liverpool v West Brom and Southampton v Watford.
The draw was conducted by former Cup winner Dennis Wise and Manchester United legend Rio Ferdinand ahead of the weekend’s final third round tie between Brighton and Crystal Palace.
Fourth round ties will take place across the weekend of 26-29 January, with winning clubs receiving £90,000 from the Emirates FA Cup prize fund.
Fourth round draw:
1 Liverpool v West Bromwich Albion
2 Peterborough United v Leicester City
3 Huddersfield Town v Birmingham City
4 Notts County v Swansea City
5 Yeovil Town v Manchester United
6 Sheffield Wednesday v Reading
7 Cardiff City v Manchester City
8 MK Dons v Coventry City
9 Millwall v Rochdale
10 Southampton v Watford
11 Middlesbrough v Brighton & Hove Albion
12 Wigan Athletic v West Ham United
13 Hull City v Nottingham Forest
14 Newport County v Tottenham Hotspur
15 Chelsea v Newcastle United
16 Sheffield United v Preston North End